PRESERVE Trial

PRESERVE trial logo

The PRESERVE Trial (Predicting the Safety and Effectiveness of Inferior Vena Cava Filters), is the first large-scale, multi-specialty, prospective clinical study to evaluate the use of inferior vena cava (IVC) filters and related follow-up treatment in the United States.

It is sponsored by IVC Filter Study Group Foundation, which is a joint collaboration between the Society for Vascular Surgery and the Society of Interventional Radiology.  

Updates

JVS-VL Article

Publication date: 02/22/23

You can now read the JVS-VL article regarding the PRESERVE trial outcomes. The article will be available as free access for a limited time.

  • Type of Research: Multicenter, prospective, open-label, nonrandomized investigation.

  • Key Findings: Only 23 clinically significant, nonfatal pulmonary emboli were diagnosed following vena cava filter (VCF) placement in 1421 patients, of whom 1019 (71.7%) had current venous thromboembolism at the time of placement. Clinically significant VCF-related adverse events were rare. Post-VCF placement deep vein thromboses (DVTs) were diagnosed in 74 (5.2%) and caval occlusions in 15 (1.1%) patients. VCFs were removed from 632 of 640 (98.8%) patients who underwent attempted removal, 620 (96.8%) at first attempt.
     
  • Take Home Message: The PRESERVE (PREdicting the Safety and Effectiveness of inferioR VEna cava filters) protocol, including formulation of a plan for VCF retrieval at placement and frequent reevaluation of patients for possible VCF removal thereafter, resulted in a high rate of VCF removal.

Read the full article

Vascular Specialist Article

Publication date: 02/22/23

Few adverse events are connected to the use of inferior vena cava (IVC) filters to help prevent deep vein blood clots from developing into pulmonary embolisms (PE), according to the findings of the Predicting the safety and effectiveness of inferior vena cava filters (PRESERVE) trial, published jointly in the Journal of Vascular and Interventional Radiology (JVIR) and the Journal of Vascular Surgery Venous and Lymphatics (JVS-VL)...

Read the Full Article

Interview with Dr. David Gillespie

Publication date: 02/22/23

Watch an interview with SVS member Dr. David Gillespie, co-principal investigator for the PRESERVE trial, as he discusses the trial's origins and outcomes. 

View the interview here

Press Release

Publication Date: 02/23/23

Few adverse events are connected to the use of inferior vena cava (IVC) filters to help prevent deep vein blood clots from developing into pulmonary embolisms (PE), according to the findings of the Predicting the Safety and Effectiveness of Inferior Vena Cava Filters (PRESERVE) trial, published jointly in the Journal of Vascular and Interventional Radiology (JVIR) and the Journal of Vascular Surgery Venous and Lymphatics (JVSVL)...

Read the release

This highly impactful study provides the real-world evidence needed when recommending IVC filter placement to protect our patients from a potentially lethal disease and when to remove that filter after it has accomplished the desired effect. It is a stellar example of collaboration across specialties for the betterment of patient care.

- Michael Dalsing, MD, DFSVS
President, Society for Vascular Surgery