BEST-CLI Resources

Best Endovascular vs. Best Surgical Therapy in Patients with Critical Limb Ischemia (BEST-CLI)

BEST-CLI is an international research study aimed at figuring out the best treatment for people with peripheral arterial disease (PAD) - also known as poor blood flow, and associated with Critical Limb Ischemia (CLI). It is Federally funded by the National Heart, Lung and Blood Institute at the National Institutes of Health. The results have been published in the New England Journal of Medicine.

BEST-CLI Resources

Upcoming Events Date Time Registration

SVS Presents...What Do the BEST-CLI Results Mean for the Vascular Surgery Community?

Apr. 12, 2023 7:00 to 8:30 p.m. CT Learn More and Register


Vascular Specialist Article Title Date of Publication
"BEST-CLI: Analysis finds correlation between WIfI stage four CLTI and reports of poorer mental health" Jan. 26, 2023
"Vascular community starts process of wrestling with findings from BEST-CLI" Jan. 1, 2023
"BEST-CLI: Optimal medical therapy adherence 'well below' recommended level at baseline" Dec. 1, 2022
"SCVS 2022: ‘We should not allow our industry relationships influence how we choose to treat patients’" Mar. 22, 2022

"First data from BEST-CLI bring surgical bypass into the forefront of discussion for patients with high-quality great saphenous vein"

Nov. 7, 2022
"BEST-CLI attracts $3.3m funding injection to continue data analysis" Nov. 3, 2022
"First results from BEST-CLI poised to reveal 'very low' quality of life for patients entering the trial, especially women" Jun. 22, 2022
"Implementing change: How adjustments in communication approach helped BEST-CLI trial register on radar" Apr. 30, 2020


Audible Bleeding Date of Publication
BEST-CLI Discussion with Principal Investigators - Alik Farber, MD and Matthew Menard, MD Aug. 17, 2019

Coming soon! 

Be on the lookout for a new BEST-CLI episode of Audible Bleeding and BEST-CLI-centric sessions for VAM23.